Protein Name uncoupling protein 2
Organism Rattus norvegicus
Gene ID 54315
Gene Symbol


UniProt P56500 (UCP2_RAT)
Relationships Total Number of functionally related compound(s) : 182
Total Number of Articles : 250

uncoupling protein 2

Gene Summary

Predicted to enable oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to glucose stimulus; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Used to study hypertension; non-alcoholic fatty liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; fatty liver disease (multiple); hypothyroidism; obstructive jaundice; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

  • dicarboxylate carrier SLC25A8
  • UCP 2
  • Uncoupling protein 2, mitochondrial
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