CPRiL

Ucp2

uncoupling protein 2

Predicted to enable several functions, including C4-dicarboxylate transmembrane transporter activity; GDP binding activity; and inorganic anion transmembrane transporter activity. Involved in several processes, including cellular response to lead ion; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial membrane. Used to study hypertension; metabolic dysfunction-associated steatotic liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; hypothyroidism; obstructive jaundice; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Jun 2025]

• dicarboxylate carrier UCP2
• UCP 2
• Uncoupling protein 2, mitochondrial
dicarboxylate carrier SLC25A8
mitochondrial uncoupling protein 2
solute carrier family 25 member 8
uncoupling protein 2 (mitochondrial, proton carrier)