Protein Name glutamate ionotropic receptor NMDA type subunit 2B
Organism Homo sapiens
Gene ID 2904
Gene Symbol


UniProt Q13224 (NMDE2_HUMAN)
Relationships Total Number of functionally related compound(s) : 464
Total Number of Articles : 739

glutamate ionotropic receptor NMDA type subunit 2B

Gene Summary

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]

  • glutamate receptor ionotropic, NMDA 2B
  • GluN2B(alt_5'UTR)
  • N-methyl D-aspartate receptor subtype 2B
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