Protein Name glutamate ionotropic receptor NMDA type subunit 2A
Organism Homo sapiens
Gene ID 2903
Gene Symbol


UniProt Q12879 (NMDE1_HUMAN), Q547U9 (Q547U9_HUMAN), Q59EW6 (Q59EW6_HUMAN), A0A6Q8PGD2 (A0A6Q8PGD2_HUMAN)
Relationships Total Number of functionally related compound(s) : 216
Total Number of Articles : 396

glutamate ionotropic receptor NMDA type subunit 2A

Gene Summary

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

  • glutamate receptor ionotropic, NMDA 2A
  • N-methyl D-aspartate receptor subtype 2A
  • N-methyl-D-aspartate receptor channel, subunit epsilon-1
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