Protein Name sirtuin 3
Organism Homo sapiens
Gene ID 23410
Gene Symbol

SIRT3

UniProt Q9NTG7 (SIR3_HUMAN)
Relationships Total Number of functionally related compound(s) : 319
Total Number of Articles : 507
Description

sirtuin 3

Gene Summary

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

synonyms
  • NAD-dependent protein deacetylase sirtuin-3, mitochondrial
  • NAD-dependent deacetylase sirtuin-3, mitochondrial
  • SIR2-like protein 3
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Properties