Protein Name troponin I3, cardiac type
Organism Homo sapiens
Gene ID 7137
Gene Symbol


UniProt P19429 (TNNI3_HUMAN), Q6FGX2 (Q6FGX2_HUMAN)
Relationships Total Number of functionally related compound(s) : 403
Total Number of Articles : 532

troponin I3, cardiac type

Gene Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]

  • troponin I, cardiac muscle
  • cardiomyopathy, dilated 2A (autosomal recessive)
  • troponin I type 3 (cardiac)
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