| Protein Name | adenylate kinase 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 204 |
| Gene Symbol | AK2 |
| UniProt | P54819 (KAD2_HUMAN), G3V213 (G3V213_HUMAN), F8VY04 (F8VY04_HUMAN), F8W1A4 (F8W1A4_HUMAN), A0A140VK93 (A0A140VK93_HUMAN) |
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Total Number of functionally related compound(s) :
44
Total Number of Articles : 32 |
Description |
adenylate kinase 2 |
| Gene Summary |
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010] |
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