| Protein Name | Kelch-like ECH-associated protein 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 117519 |
| Gene Symbol | Keap1 |
| UniProt | G3V8U2 (G3V8U2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
278
Total Number of Articles : 271 |
Description |
Kelch-like ECH-associated protein 1 |
| Gene Summary |
Predicted to enable several functions, including disordered domain specific binding activity; transcription regulator inhibitor activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including response to immobilization stress; response to thyroid hormone; and selenium compound metabolic process. Located in adherens junction and focal adhesion. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |