Protein Name Kelch-like ECH-associated protein 1
Organism Rattus norvegicus
Gene ID 117519
Gene Symbol

Keap1

UniProt G3V8U2 (G3V8U2_RAT)
Relationships Total Number of functionally related compound(s) : 278
Total Number of Articles : 271
Description

Kelch-like ECH-associated protein 1

Gene Summary

Predicted to enable disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including regulation of gene expression; response to thyroid hormone; and selenium compound metabolic process. Located in several cellular components, including adherens junction; focal adhesion; and nucleus. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • kelch-like ECH-associated protein 1
  • cytosolic inhibitor of Nrf2
  • Inrf2
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Properties