Protein Name ras homolog family member G
Organism Homo sapiens
Gene ID 391
Gene Symbol


UniProt P84095 (RHOG_HUMAN), Q6ICQ8 (Q6ICQ8_HUMAN)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 43

ras homolog family member G

Gene Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

  • rho-related GTP-binding protein RhoG
  • ras homolog gene family, member G (rho G)
  • ARHG
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