CPRiL

Protein Name	potassium inwardly-rectifying channel, subfamily J, member 6
Organism	Mus musculus
Gene ID	16522
Gene Symbol	Kcnj6
UniProt	P48542 (KCNJ6_MOUSE), Q0VB45 (Q0VB45_MOUSE), Q8C4T8 (Q8C4T8_MOUSE), Q8C8Y6 (Q8C8Y6_MOUSE), A0A0R4J239 (A0A0R4J239_MOUSE), A0A338P6L0 (A0A338P6L0_MOUSE)
Relationships	Total Number of functionally related compound(s) : 45 Total Number of Articles : 61
Description	potassium inwardly-rectifying channel, subfamily J, member 6
Gene Summary	Enables inward rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Contributes to G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in membrane. Part of inward rectifier potassium channel complex. Is active in parallel fiber to Purkinje cell synapse; postsynapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Jun 2025]
synonyms	G protein-activated inward rectifier potassium channel 2 G-protein-coupled inward rectifier K+ channel 2-1 G-protein-coupled inward rectifier K+ channel 2-A G-protein-coupled inward rectifier K+ channel 2-B G-protein-coupled inward rectifier K+ channel 2-C GIRK-2 inward rectifier K(+) channel Kir3.2 potassium channel, inwardly rectifying subfamily J member 6 potassium inwardly-rectifying channel J6 BIR1 GIRK2 KATP2 KCNJ7 Kir3.2 weaver wv Click to show/hide the synonyms
Properties