| Protein Name | tribbles pseudokinase 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 57761 |
| Gene Symbol | TRIB3 |
| UniProt | Q96RU7 (TRIB3_HUMAN), B4DMM9 (B4DMM9_HUMAN), J3KR25 (J3KR25_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
120
Total Number of Articles : 132 |
Description |
tribbles pseudokinase 3 |
| Gene Summary |
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] |
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