Protein Name neutral sphingomyelinase activation associated factor
Organism Homo sapiens
Gene ID 8439
Gene Symbol

NSMAF

UniProt Q92636 (FAN_HUMAN)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 27
Description

neutral sphingomyelinase activation associated factor

Gene Summary

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

synonyms
  • protein FAN
  • factor associated with N-SMase activation
  • factor associated with neutral sphingomyelinase activation
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Properties