| Protein Name | pericentrin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5116 |
| Gene Symbol | PCNT |
| UniProt | O95613 (PCNT_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
67
Total Number of Articles : 41 |
Description |
pericentrin |
| Gene Summary |
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
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