| Protein Name | ubiquitin specific peptidase 20 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10868 |
| Gene Symbol | USP20 |
| UniProt | Q9Y2K6 (UBP20_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 8 |
Description |
ubiquitin specific peptidase 20 |
| Gene Summary |
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013] |
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