| Protein Name | histamine N-methyltransferase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3176 |
| Gene Symbol | HNMT |
| UniProt | P50135 (HNMT_HUMAN), B4DWC1 (B4DWC1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
215
Total Number of Articles : 230 |
Description |
histamine N-methyltransferase |
| Gene Summary |
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] |
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