| Protein Name | axin 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8313 |
| Gene Symbol | AXIN2 |
| UniProt | Q9Y2T1 (AXIN2_HUMAN), E7ES00 (E7ES00_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
85
Total Number of Articles : 76 |
Description |
axin 2 |
| Gene Summary |
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
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