Protein Name membrane metalloendopeptidase
Organism Homo sapiens
Gene ID 4311
Gene Symbol


UniProt P08473 (NEP_HUMAN)
Relationships Total Number of functionally related compound(s) : 625
Total Number of Articles : 903

membrane metalloendopeptidase

Gene Summary

The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

  • neprilysin
  • atriopeptidase
  • common acute lymphocytic leukemia antigen
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