| Protein Name | CD40 antigen |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21939 |
| Gene Symbol | Cd40 |
| UniProt | P27512 (TNR5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
349
Total Number of Articles : 390 |
Description |
CD40 antigen |
| Gene Summary |
Predicted to enable several functions, including antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and intracellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to protozoan; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of B cell activation. Located in external side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; limb; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Jun 2025] |
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