Protein Name recombination signal binding protein for immunoglobulin kappa J region
Organism Homo sapiens
Gene ID 3516
Gene Symbol

RBPJ

UniProt Q06330 (SUH_HUMAN)
Relationships Total Number of functionally related compound(s) : 71
Total Number of Articles : 69
Description

recombination signal binding protein for immunoglobulin kappa J region

Gene Summary

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

synonyms
  • recombining binding protein suppressor of hairless
  • H-2K binding factor-2
  • immunoglobulin kappa J region recombination signal binding protein 1
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Properties