Protein Name polynucleotide kinase 3'-phosphatase
Organism Homo sapiens
Gene ID 11284
Gene Symbol

PNKP

UniProt Q96T60 (PNKP_HUMAN)
Relationships Total Number of functionally related compound(s) : 135
Total Number of Articles : 120
Description

polynucleotide kinase 3'-phosphatase

Gene Summary

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]

synonyms
  • bifunctional polynucleotide phosphatase/kinase
  • DNA 5'-kinase/3'-phosphatase
  • Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)
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Properties