Protein Name programmed cell death 1
Organism Homo sapiens
Gene ID 5133
Gene Symbol


UniProt Q15116 (PDCD1_HUMAN), A0A0M3M0G7 (A0A0M3M0G7_HUMAN)
Relationships Total Number of functionally related compound(s) : 637
Total Number of Articles : 828

programmed cell death 1

Gene Summary

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]

  • programmed cell death protein 1
  • programmed cell death 1 protein
  • protein PD-1
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