| Protein Name | programmed cell death 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5133 |
| Gene Symbol | PDCD1 |
| UniProt | Q15116 (PDCD1_HUMAN), A0A0M3M0G7 (A0A0M3M0G7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
637
Total Number of Articles : 828 |
Description |
programmed cell death 1 |
| Gene Summary |
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
| synonyms |
|
| Properties | |