| Protein Name | PDZ and LIM domain 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 64236 |
| Gene Symbol | PDLIM2 |
| UniProt | Q96JY6 (PDLI2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
11
Total Number of Articles : 12 |
Description |
PDZ and LIM domain 2 |
| Gene Summary |
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
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