| Protein Name | lymphocyte protein tyrosine kinase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16818 |
| Gene Symbol | Lck |
| UniProt | P06240 (LCK_MOUSE), E9Q696 (E9Q696_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
139
Total Number of Articles : 169 |
Description |
lymphocyte protein tyrosine kinase |
| Gene Summary |
Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jun 2025] |
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