Protein Name sorbitol dehydrogenase
Organism Homo sapiens
Gene ID 6652
Gene Symbol


UniProt Q00796 (DHSO_HUMAN)
Relationships Total Number of functionally related compound(s) : 73
Total Number of Articles : 62

sorbitol dehydrogenase

Gene Summary

Sorbitol dehydrogenase (SORD; EC catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

  • sorbitol dehydrogenase
  • (R,R)-butanediol dehydrogenase
  • L-iditol 2-dehydrogenase
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