| Protein Name | prohibitin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18673 |
| Gene Symbol | Phb1 |
| UniProt | P67778 (PHB_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
42
Total Number of Articles : 36 |
Description |
prohibitin 1 |
| Gene Summary |
Enables transcription corepressor activity. Involved in several processes, including modulation by host of viral RNA genome replication; positive regulation of immunoglobulin production; and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in cerebral cortex ventricular layer; cortical plate; ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |