Protein Name Rap guanine nucleotide exchange factor 5
Organism Homo sapiens
Gene ID 9771
Gene Symbol


UniProt Q92565 (RPGF5_HUMAN), A8MQ07 (A8MQ07_HUMAN), Q5JPD2 (Q5JPD2_HUMAN)
Relationships Total Number of functionally related compound(s) : 150
Total Number of Articles : 272

Rap guanine nucleotide exchange factor 5

Gene Summary

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

  • rap guanine nucleotide exchange factor 5
  • M-Ras-regulated GEF
  • M-Ras-regulated Rap GEF
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