Protein Name | platelet derived growth factor subunit A |
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Organism | Homo sapiens |
Gene ID | 5154 |
Gene Symbol | PDGFA |
UniProt | P04085 (PDGFA_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
117
Total Number of Articles : 121 |
Description |
platelet derived growth factor subunit A |
Gene Summary |
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
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