Protein Name platelet derived growth factor subunit A
Organism Homo sapiens
Gene ID 5154
Gene Symbol

PDGFA

UniProt P04085 (PDGFA_HUMAN)
Relationships Total Number of functionally related compound(s) : 117
Total Number of Articles : 121
Description

platelet derived growth factor subunit A

Gene Summary

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

synonyms
  • platelet-derived growth factor subunit A
  • PDGF A-chain
  • PDGF subunit A
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Properties