Protein Name collagen type VII alpha 1 chain
Organism Homo sapiens
Gene ID 1294
Gene Symbol


UniProt Q02388 (CO7A1_HUMAN), Q59F16 (Q59F16_HUMAN)
Relationships Total Number of functionally related compound(s) : 36
Total Number of Articles : 86

collagen type VII alpha 1 chain

Gene Summary

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]

  • collagen alpha-1(VII) chain
  • LC collagen
  • collagen VII, alpha-1 polypeptide
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