Protein Name nuclear receptor subfamily 1, group H, member 2
Organism Mus musculus
Gene ID 22260
Gene Symbol

Nr1h2

UniProt Q60644 (NR1H2_MOUSE), Q8BP65 (Q8BP65_MOUSE)
Relationships Total Number of functionally related compound(s) : 115
Total Number of Articles : 176
Description

nuclear receptor subfamily 1, group H, member 2

Gene Summary

Enables DNA binding activity; nuclear receptor activity; and retinoid X receptor binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of transport; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • oxysterols receptor LXR-beta
  • LXR beta
  • liver X receptor beta
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Properties