Protein Name ret proto-oncogene
Organism Rattus norvegicus
Gene ID 24716
Gene Symbol

Ret

UniProt G3V9H8 (RET_RAT)
Relationships Total Number of functionally related compound(s) : 93
Total Number of Articles : 84
Description

ret proto-oncogene

Gene Summary

Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including early endosome; membrane raft; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • proto-oncogene tyrosine-protein kinase receptor Ret
  • Ret gene for receptor tyrosin
  • Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
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Properties