| Protein Name | anterior gradient 3, protein disulphide isomerase family member |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 155465 |
| Gene Symbol | AGR3 |
| UniProt | Q8TD06 (AGR3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
96
Total Number of Articles : 57 |
Description |
anterior gradient 3, protein disulphide isomerase family member |
| Gene Summary |
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016] |
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