Protein Name MHC class I polypeptide-related sequence A
Organism Homo sapiens
Gene ID 100507436
Gene Symbol


UniProt Q29983 (MICA_HUMAN), A0A0G2JJ55 (A0A0G2JJ55_HUMAN), A0A024RCL3 (A0A024RCL3_HUMAN), Q96QC4 (Q96QC4_HUMAN)
Relationships Total Number of functionally related compound(s) : 581
Total Number of Articles : 631

MHC class I polypeptide-related sequence A

Gene Summary

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

  • MHC class I polypeptide-related sequence A
  • HLA class I antigen
  • MHC class I chain-related protein A
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