Protein Name nuclear mitotic apparatus protein 1
Organism Homo sapiens
Gene ID 4926
Gene Symbol

NUMA1

UniProt Q14980 (NUMA1_HUMAN), Q3SYK8 (Q3SYK8_HUMAN), A0A024R5M9 (A0A024R5M9_HUMAN), Q4LE64 (Q4LE64_HUMAN)
Relationships Total Number of functionally related compound(s) : 75
Total Number of Articles : 57
Description

nuclear mitotic apparatus protein 1

Gene Summary

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

synonyms
  • nuclear mitotic apparatus protein 1
  • SP-H antigen
  • centrophilin stabilizes mitotic spindle in mitotic cells
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Properties