Protein Name selectin P ligand
Organism Homo sapiens
Gene ID 6404
Gene Symbol


UniProt Q14242 (SELPL_HUMAN)
Relationships Total Number of functionally related compound(s) : 494
Total Number of Articles : 471

selectin P ligand

Gene Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

  • P-selectin glycoprotein ligand 1
  • cutaneous lymphocyte-associated associated antigen
  • CD162
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