Protein Name carboxyl ester lipase
Organism Homo sapiens
Gene ID 1056
Gene Symbol


UniProt O75612 (O75612_HUMAN), B4DSX9 (B4DSX9_HUMAN), Q86SR3 (Q86SR3_HUMAN)
Relationships Total Number of functionally related compound(s) : 452
Total Number of Articles : 360

carboxyl ester lipase

Gene Summary

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

  • bile salt-activated lipase
  • bucelipase
  • carboxyl ester hydrolase
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