Protein Name 15-hydroxyprostaglandin dehydrogenase
Organism Homo sapiens
Gene ID 3248
Gene Symbol

HPGD

UniProt P15428 (PGDH_HUMAN)
Relationships Total Number of functionally related compound(s) : 145
Total Number of Articles : 191
Description

15-hydroxyprostaglandin dehydrogenase

Gene Summary

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

synonyms
  • 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • 15-hydroxyprostaglandin dehydrogenase (NAD(+))
  • NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
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Properties