| Protein Name | decorin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1634 |
| Gene Symbol | DCN |
| UniProt | P07585 (PGS2_HUMAN), Q6FH10 (Q6FH10_HUMAN), A0A024RBG6 (A0A024RBG6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
160
Total Number of Articles : 162 |
Description |
decorin |
| Gene Summary |
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015] |
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