Protein Name decorin
Organism Homo sapiens
Gene ID 1634
Gene Symbol


UniProt P07585 (PGS2_HUMAN), Q6FH10 (Q6FH10_HUMAN), A0A024RBG6 (A0A024RBG6_HUMAN)
Relationships Total Number of functionally related compound(s) : 160
Total Number of Articles : 162


Gene Summary

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

  • decorin
  • bone proteoglycan II
  • dermatan sulphate proteoglycans II
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