| Protein Name | recombination activating gene 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19374 |
| Gene Symbol | Rag2 |
| UniProt | P21784 (RAG2_MOUSE), Q542D1 (Q542D1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
64
Total Number of Articles : 67 |
Description |
recombination activating gene 2 |
| Gene Summary |
Enables several functions, including histone H3K4me3 reader activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in T cell differentiation in thymus; V(D)J recombination; and pre-B cell allelic exclusion. Acts upstream of or within several processes, including B cell homeostatic proliferation; lymphocyte differentiation; and positive regulation of organ growth. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |