Protein Name recombination activating gene 2
Organism Mus musculus
Gene ID 19374
Gene Symbol

Rag2

UniProt P21784 (RAG2_MOUSE), Q542D1 (Q542D1_MOUSE)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 67
Description

recombination activating gene 2

Gene Summary

Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and zinc ion binding activity. Involved in V(D)J recombination and pre-B cell allelic exclusion. Acts upstream of or within several processes, including B cell homeostatic proliferation; lymphocyte differentiation; and positive regulation of organ growth. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • V(D)J recombination-activating protein 2
  • recombinase activating gene 2
  • Rag-2
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Properties