Protein Name prostaglandin G/H synthase 1
Organism Ovis aries
Gene ID 443551
Gene Symbol

PTGS1

UniProt P05979 (PGH1_SHEEP)
Relationships Total Number of functionally related compound(s) : 28
Total Number of Articles : 25
Description

prostaglandin-endoperoxide synthase 1

Gene Summary

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]

synonyms
  • prostaglandin G/H synthase 1
  • PGH synthase 1
  • PHS 1
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Properties