Protein Name cadherin 1
Organism Rattus norvegicus
Gene ID 83502
Gene Symbol

Cdh1

UniProt Q9R0T4 (CADH1_RAT)
Relationships Total Number of functionally related compound(s) : 207
Total Number of Articles : 230
Description

cadherin 1

Gene Summary

Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • cadherin-1
  • E-cadherin
  • epithelial cadherin
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Properties