| Protein Name | acetyl-CoA carboxylase alpha |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 31 |
| Gene Symbol | ACACA |
| UniProt | Q13085 (ACACA_HUMAN), A0A024R0Y2 (A0A024R0Y2_HUMAN), Q7Z5W8 (Q7Z5W8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
185
Total Number of Articles : 216 |
Description |
acetyl-CoA carboxylase alpha |
| Gene Summary |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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