CPRiL

Protein Name	succinate-CoA ligase ADP-forming subunit beta
Organism	Homo sapiens
Gene ID	8803
Gene Symbol	SUCLA2
UniProt	Q9P2R7 (SUCB1_HUMAN), E5KS60 (E5KS60_HUMAN), Q9Y4T0 (Q9Y4T0_HUMAN)
Relationships	Total Number of functionally related compound(s) : 59 Total Number of Articles : 49
Description	succinate-CoA ligase ADP-forming subunit beta
Gene Summary	Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
synonyms	succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial ATP-specific succinyl-CoA synthetase subunit beta ATP-specific succinyl-CoA synthetase, beta subunit long intergenic non-protein coding RNA 444 mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta renal carcinoma antigen NY-REN-39 succinate-CoA ligase ADP-forming beta subunit succinate-CoA ligase beta subunit succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial succinyl-CoA synthetase beta-A chain A-BETA A-SCS LINC00444 MTDPS5 SCS-betaA Click to show/hide the synonyms
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