| Protein Name | N-terminal Asn amidase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18203 |
| Gene Symbol | Ntan1 |
| UniProt | Q64311 (NTAN1_MOUSE), D3YZ99 (D3YZ99_MOUSE), Q8BRX4 (Q8BRX4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
4
Total Number of Articles : 3 |
Description |
N-terminal Asn amidase |
| Gene Summary |
The protein encoded by this gene functions in a step-wise protein degradation process through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asparagine residues on proteins to produce N-terminal L-Aspartate. L-Aspartate substrates are subsequently conjugated to L-Arginine, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Mice with a knock-out of this gene are viable, fertile, and outwardly normal, but show impairments in spontaneous activity and spatial memory, relative to their wild-type counterparts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
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| Properties | |