Protein Name dentin sialophosphoprotein
Organism Homo sapiens
Gene ID 1834
Gene Symbol


Relationships Total Number of functionally related compound(s) : 181
Total Number of Articles : 145

dentin sialophosphoprotein

Gene Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]

  • dentin sialophosphoprotein
  • deafness, autosomal dominant 39
  • dentin phosphophoryn
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