Protein Name peroxisome proliferator activated receptor delta
Organism Homo sapiens
Gene ID 5467
Gene Symbol


UniProt Q03181 (PPARD_HUMAN), A0A024RCW6 (A0A024RCW6_HUMAN), F1D8S7 (F1D8S7_HUMAN)
Relationships Total Number of functionally related compound(s) : 429
Total Number of Articles : 638

peroxisome proliferator activated receptor delta

Gene Summary

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

  • peroxisome proliferator-activated receptor delta
  • PPAR-beta
  • PPAR-delta
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