| Protein Name | complement C3b/C4b receptor 1 (Knops blood group) |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1378 |
| Gene Symbol | CR1 |
| UniProt | P17927 (CR1_HUMAN), E9PDY4 (E9PDY4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
288
Total Number of Articles : 288 |
Description |
complement C3b/C4b receptor 1 (Knops blood group) |
| Gene Summary |
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] |
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