| Protein Name | malate dehydrogenase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24551 |
| Gene Symbol | Mdh1 |
| UniProt | O88989 (MDHC_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 10 |
Description |
malate dehydrogenase 1 |
| Gene Summary |
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. [provided by RefSeq, Feb 2016] |
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| Properties | |