| Protein Name | GATA binding protein 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14463 |
| Gene Symbol | Gata4 |
| UniProt | Q08369 (GATA4_MOUSE), Q3UYJ1 (Q3UYJ1_MOUSE), E9PXW9 (E9PXW9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
125
Total Number of Articles : 165 |
Description |
GATA binding protein 4 |
| Gene Summary |
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including heart development; negative regulation of cell death; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; gut; heart; and reproductive system. Used to study atrial heart septal defect 2 and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022] |
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