| Protein Name | neuropilin 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8829 |
| Gene Symbol | NRP1 |
| UniProt | O14786 (NRP1_HUMAN), Q68DN3 (Q68DN3_HUMAN), Q59F20 (Q59F20_HUMAN), Q6X907 (Q6X907_HUMAN), A8K9V7 (A8K9V7_HUMAN), Q6AWA9 (Q6AWA9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
272
Total Number of Articles : 278 |
Description |
neuropilin 1 |
| Gene Summary |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020] |
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| Properties | |