Protein Name FTO alpha-ketoglutarate dependent dioxygenase
Organism Homo sapiens
Gene ID 79068
Gene Symbol


UniProt Q9C0B1 (FTO_HUMAN), A0A1B0GTC5 (A0A1B0GTC5_HUMAN), B3KU60 (B3KU60_HUMAN), Q99770 (Q99770_HUMAN)
Relationships Total Number of functionally related compound(s) : 528
Total Number of Articles : 667

FTO alpha-ketoglutarate dependent dioxygenase

Gene Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

  • alpha-ketoglutarate-dependent dioxygenase FTO
  • AlkB homolog 9
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
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