| Protein Name | upper zone of growth plate and cartilage matrix associated |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 221044 |
| Gene Symbol | UCMA |
| UniProt | Q8WVF2 (UCMA_HUMAN), A0A067XJX6 (A0A067XJX6_HUMAN), A0A067XJP8 (A0A067XJP8_HUMAN), A0A067XKV3 (A0A067XKV3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
19
Total Number of Articles : 19 |
Description |
upper zone of growth plate and cartilage matrix associated |
| Gene Summary |
This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015] |
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